Public Health Department (Main Office)

Monday - Friday 8-5 (excluding County Holidays)

2191 Johnson Avenue
San Luis Obispo, CA 93401

Main Public Health Line

(805) 781-5500

24-Hour Recorded Information Line

(805) 788-2903

Clinic Locations

View all of our clinic locations.


English; Spanish; interpretation services available by telephone for other languages at no cost

If you have a life-threatening, medical emergency, please dial 9-1-1.

For the latest information on COVID-19 in SLO County, including vaccine information, please visit

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